REPOLARIZATION ASSAYS

CARDIAC ACTION POTENTIAL DURATION (APD) ASSAY PDF Determine the effects of drugs on the resting potential,and on action potential duration, amplitude and maximum. GLP or non-GLP assays are available in canine or rabbit Purkinje fibers and Non-GLP assays are available in acutely isolated guinea pig, rat or canine myocytes. The APD assay, together with the hERG assay, is an effective indicator of mixed ion channel effects (See MDA Assay)

MICE (Mixed Ion Channel Effects) DETECTION ASSAY (MDA) PDF
Reveal the presence of MICE (Mixed Ion Channel Effects) and identify the "conflicting" cardiac ion channel with this combined hERG and APD assay, plus ion channel screen test. GLP or non-GLP assays available.

CT-QT ISOLATED RABBIT HEART QT PROLONGATION ASSAY PDF
Determine the effects of drugs on the QT interval, contractility (LVP, dP/dt _{max. & min.}), and the duration of the monophasic action potential (MAPD_{60, 90}) in ex-vivo rabbit hearts.