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ChanTest to Highlight Most-Comprehensive Range of Ion Channel Profiling Screens and Consultation Services at 14th Annual SBS Conference, Booth 1104PDF

ChanTest to Highlight Expanded Ion Channel Testing Services for Preclinical Safety at ToxExpo, Including the World’s Largest Catalog of Validated Ion Channels, Booth 2504PDF

ChanTest Receives Expansion Capital From Ampersand VenturesPDF

Cambridge BioScience appointed as European Distributor for ChanTestPDF

ChanTest Fourth Quarter Newsletter PDF

ChanTest is awarded $4.7 million BRCP grant!
The BRCP was created by the State of Ohio to support biomedical and biotech research, leading to commercialization in Ohio and long-term improvements to the health of Ohioans. ChanTest, Inc. was awarded $4.7 million to develop the Ion Channel Panel Screening for Drug Safety and Discovery.  This project involves the creation of 72 ion channel cell lines that will facilitate and enhance the discovery of drugs for diseases that have ion channels as primary targets.

ChanTest ranked as the "Most Trusted Ion Channel Screening" CSO
ChanTest was recently ranked as the "most trusted fee-for-service provider" for ion channel safety screening by John Comley's 2006 HTstec Ion Channel Trends Survey.The survey polls lab personnel from large pharma, medium, and small pharma, universities and government labs that outsource ion channel safety studies.

Super FASTPatch®
Fastest functional ion channel screen by automated patch clamp

 Cardiac Channel Panels
Automated, functional selectivity profiling of cardiac ion channels

FASTPatch® AUTOMATED PATCH-CLAMP SCREENING
High throughput, functional screening for hERG risk provides prompt, cost-effective results

FAST & Lite™ COMPREHENSIVE HIGH THROUGHPUT SCREENING
HERG-Lite® & FASTPatch® together for the most comprehensive hERG screening

GLP Dose Solution Analysis
Verify applied concentrations with our GLP HPLC analytical sample testing of dose solutions for multi-concentration assays

Successful FDA Inspection
ChanTest had its first FDA inspection in September, 2004. We are pleased to announce that ChanTest did not receive any 483 observations.

CT-QT™ assay
Our ex vivo rabbit heart Langendorff assay can be used to evaluate QT risk and the potential for mixed ion channel effects, as a rapid, cost-effective complement to vivo QT studies.

NCX sodium-calcium exchange current dose-response assay
To determine the potential contribution of drug effects on hNCX1 to action potential prolongation and delayed afterdepolarizations.

ChanTest's accuracy & repeatability
95% Confidence Limits consistently delivered; results in IC50 variations of only 1.1 - 1.8 for ChanTest (within circles below) vs. the wide range of IC-50 results published in literature (range in vertical lines below ref. J. Pharm.Tox.Methods 2004)

ChanTest Wins a 2004 NEO Success Award
ChanTest has been chosen as a top-performing company in our region. Winners are chosen from the 18 counties of Northeast Ohio based on a two-year growth formula that includes revenue, profitability and number of employees. The winners of this prestigious award have shown sustained success in growing their companies through increased sales and profitability, and impacting their communities by boosting payrolls.

HERG Lite® High Throughput Screen
"Think Outside the Block!"
The most comprehensive HTS assay for identifying hERG risk! HERG-Lite® is more comprehensive, rapid & cost-effective than Rb Flux, Radio-Ligand Displacement, or Dye-Based methods. Only HERG-Lite® will identify direct hERG blockers AND drugs that block hERG trafficking.

HERG-TA^TM Assay
when drugs are identified as interfering with hERG trafficking; only ChanTest's new HERG-TA^TM assay will provide the complete information necessary to evaluate those drugs!

ChanTest's hERG cell line is fully validated!
ChanTest's HEK293/hERG cell line offers a valuable regulatory advantage because of its:

• complete documentation of passage number, history, methods and techniques of cell line generation;
• validation of hERG protein expression, biophysical properties, and pharmacology; and,
• error-free identity with published cDNA sequence data.

Rabbit Purkinje fiber Action Potential Duration (APD) assay available
ChanTest recently re-validated its Action Potential Duration assay using rabbit Purkinje fibers. After conducting both GLP and non-GLP assays on canine Purkinje fibers during the past two years, ChanTest has added more sensitive, rabbit APD GLP assay.