ChanTest publications
ChanTest scientists have published more than 300 articles in peer-reviewed journals, many of which are listed below. Downloadable PDF versions of many of our most popular articles are available here – just click on the article title.
| The action potential and comparative pharmacology of stem cell-derived human cardiomyocytes. | |
| Peng S, Lacerca AE, Kirsch GE, Brown, AM, Bruening-Wright A. J Pharmacol Toxicol Methods. 2010; in press. |
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| Vanoxerine: cellular mechanism of a new antiarrhythmic. | |
| Lacerda AE, Kuryshev YA, Yan GX, Waldo AL, Brown AM. 2010;21(3):301-310. J Cardiovasc Electrophysiol. |
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| Vanoxerine, a new drug for terminating atrial fibrillation and flutter. J Cardiovasc Electrophysiol. | |
| Matsumoto N, Khrestian CM, Ryu K, Lacerda AE, Brown AM, Waldo AL. 2010;21(3):311-319. |
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| High throughput functional screening of an ion channel library for drug safety and efficacy. |
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| Brown AM. 2009. 38(3):273-278. Eur Biophys J. |
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| Test article concentrations in the hERG assay: losses through perfusion, solubility and stability. |
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| Brimecombe JC, Kirsch GE, Brown AM. 2009. 59(1):29-34. J Pharmacol Toxicol Methods. |
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| Alfuzosin delays cardiac repolarization by a novel mechanism | |
| Lacerda AE, Kuryshev YA, Chen Y, Renganathan M, Eng H, Danthi SJ, Kramer JW, Yang T, Brown AM (2008) J Pharmacol Exp Ther. 324(2):427-433 |
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| The KCNQ/M-current modulates arterial baroreceptor function at the sensory terminal in rats | |
| Wladyka CL, Feng B, Glazebrook PA, Schild JH, Kunze DL (2008) J Physiol. 586(3):795-802 |
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| Evidence for a deep pore activation gate in small conductance Ca2+-activated K+ channels | |
| Bruening-Wright A, Lee WS, Maylie J, Adelman JP (2007). J Gen Physiol. 130(6):601-610 |
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| Kinetic relationship between S4 and the activation gate in spHCN channels | |
| Bruening-Wright A, Elinder F, Larsson P | |
| (2007) J Gen Physiol. 130(1):71-81 | |
| Slow conformational changes of the voltage sensor during the mode shift in HCN channels | |
| Bruening-Wright A, Larsson HP | |
| (2007) J Neurosci. 27(2):270-278 | |
| Differential modulation by nicotine of substantia nigra versus ventral tegmental area dopamine neurons | |
| Keath JR, Iacoviello MP, Barrett LE, Mansvelder HD, McGehee DS | |
| (2007) J Neurophysiol. 98(6):3388-3396 | |
| Luminal chloride dependent activation of endosome calcium channels: patch-clamp study of enlarged endosomes | |
| Saito M, Hanson P, Schlesinger P | |
| (2007) J Biol Chem. 282(37):27327-27333 | |
| Otopetrin 1 activation by purinergic nucleotides regulates intracellular calcium | |
| Hughes I, Saito M, Schlesinger PH, Ornitz1 DM | |
| (2007) Proc Natl Acad Sci USA. 104(29):12023–12028 | |
| KCNQ/M-currents contribute to the resting membrane potential in rat visceral sensory neurons | |
| Wladyka CL, Kunze DL (2006) J Physiol. 575(1):175-189 |
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| A "sample-and-hold" pulse-counting integrator as a mechanism for graded memory underlying sensorimotor adaptation | |
| Oestreich J, Dembrow NC, Zakon HH | |
| (2006). Neuron 49(4):577-588 | |
| The Bax pore in liposomes, biophysics | |
| Schlesinger PH, Saito M | |
| (2006) Cell Death Differ. 13:1403-1408 | |
| HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk | |
| Wible BA, Hawryluk P, Ficker E, Kuryshev YA, Kirsch G, Brown AM (2005) J Pharmacol Toxicol Methods. 52(1):136-145 |
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| Pentamidine-induced long QT syndrome and block of hERG trafficking | |
| Kuryshev YA, Ficker E, Wang L, Hawryluk P, Dennia AT, Wible BA, Brown AM, Kang J, Chen XL, Sawamura K, Reynolds W, Rampe D. (2005) J Pharmacol Exp Ther. 312(1):316-323 |
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| The ion channel narrow abdomen is critical for neural output of the Drosophila circadian pacemaker | |
| Lear BC, Lin JM, Keath JR, McGill J, Raman IM, Allada R | |
| (2005) Neuron. 48(6):965-976 | |
| Species-specific differences in sensorimotor adaptation are correlated with differences in social structure | |
| Oestreich J, Zakon HH | |
| (2005) J Comp Physiol A191(9):845-856 | |
| L-citrulline immunoreactivity reveals nitric oxide production in the electromotor and electrosensory systems of the weakly electric fish, Apteronotus leptorhynchus | |
| Smith GT, Allen AR, Oestreich J, Gammie SC | |
| (2005) Brain Behav Evol. 65(1):1-13 | |
| Drugs, hERG and sudden death | |
| Brown AM (2004) Cell Calcium 35(6):543-547 |
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| Direct block of hERG potassium channels by the protein kinase C inhibitor bisindolylmaleimide I (GF109203X) | |
| Thomas D, Hammerling BS, Wimmer AB, Wu K, Ficker EK, Kuryshev YA, Scherer D, Kiehn J, Katus HA, Schoels W, Karle CA (2004). Cardiovasc Res. 64(3):467-476 |
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| Long-lived retrograde fluorescent labeling of corticospinal neurons in the living animal | |
| Suzuki T, Abe Y, McGehee DS, Keath JR, Sharma K, Brorson JR | |
| (2004) Brain Res Protoc. 13(3):183-188 | |
| Inhibition of cardiac hERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action | |
| Thomas D, Hammerling BC, Wu K, Wimmer AB, Ficker E, Kirsch GE, Kochan MC, Wible BA, Scholz EP, Zitron E, Kathofer S, Kreye VA, Katus HA, Schoels W, Karle CA, Kiehn J | |
| (2004). Br J Pharmacol 142:485-494 | |
| Inhibition of human ether-a-go-go-related gene potassium channels by alpha a-aderenoceptor antagonists prazosin, doxazosin and terazosin | |
| Thomas D, Wimmer AB, Wu K, Hammerling BC, Ficker E, Kuryshev YA, Kiehn J, Katus HA, Schoels W, Karle CA | |
| (2004). Naunyn Schmiedebergs Arch Pharmacol 369:462-472 | |
| Variability in the measurement of hERG potassium channel inhibition: effects of temperature and stimulus pattern | |
| Kirsch GE, Trepakova ES, Brimecombe JC, Sidach SS, Erickson HD, Kochan MC, Shyjka LM, Lacerda AE, Brown AM | |
| (2004). J Pharmacol Toxicol Methods 50:93-101 | |
| Mechanisms of arsenic-induced prolongation of cardiac repolarization | |
| Ficker E, Kuryshev YA, Dennis AT, Obejero-Paz CA, Wang L, Wible BA, Brown AM | |
| (2004). Mol Pharmacol 66:33-44 | |
| Factors affecting habituation of PC12 cells to ATP | |
| Keath JR, Westhead EW (2004). Eur J Biochem. 271(20):4034-4041 |
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| Diffusion of single cardiac ryanodine receptor (RyR2) in planar lipid bilayers is decreased by Annexin-12 | |
| Peng S, Publicover N, Airey J, Haigler H, Hall J, Zhang J, Chen SRW, Stuko J (2004). Biophys J. 86(1):145-151 |
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| Imaging single cardiac ryanodine receptors (RyR2) Ca2+ fluxes in lipid bilayers | |
| Peng S, Publicover N, Kargacin G, Duan D, Airey J, Sutko J (2004). Biophys J. 86(1):134-144 |
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| The common SCN5A mutation R1193Q causes LQTS-type electrophysiological alterations of the cardiac sodium channel | |
| Wang Q, Chen S, Chen Q, Wan X, Shen J, Hoeltge GA, Timur AA, Keating MT, Kirsch GE | |
| (2004). J Med Genet 41:e66 | |
| Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel hERG | |
| Ficker E, Dennis AT, Wang L, Brown AM | |
| (2003). Circ Res 92:e87-e100 | |
| Small conductance Ca2+-activated K+ channels and calmodulin: cell surface expression and gating | |
| Lee WS, Ngo-Anh TJ, Bruening-Wright A, Maylie J, Adelman JP (2003). J Biol Chem. 278(28):25940-25946 |
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| CFTR: what's it like inside the pore? | |
| Liu X, Smith SS, Dawson DC | |
| (2003) J Exp Zoolog A. 300(1):69-75 | |
| Short- and long-term modulation of synaptic inputs to brain reward areas by nicotine | |
| Fagen ZM, Mansvelder HD, Keath JR, McGehee DS | |
| (2003) PNAS. 1003:183-188 | |
| Wolframin expression induces novel ion channel activity in endoplasmic reticulum membranes and increases intracellular calcium | |
| Osman AA, Saito M, Makepeace C, Permutt MA, Schlesinger P, Mueckler M | |
| (2003) J Biol Chem. 278:52755-52762 | |
| Protein kinase A-mediated phosphorylation of hERG potassium channels in a human cell line | |
| Wei Z, Thomas D, Karle CA, Kathofer S, Schenkel J, Kreye VA, Ficker E, Wible BA, Kiehn J | |
| (2002). Chin Med J (Engl) 115:668-676 | |
| SCMTR: a chloride-selective, membrane-anchored peptide channel that exhibits voltage gating | |
| Schlesinger PH, Ferdani R, Liu J, Pajewska J, Pajewski R, Saito M, Shabany H, Gokel GW | |
| (2002) J Am Chem Soc. 124:1848-1849 | |
| Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas | |
| Mansvelder HD, Keath JR, McGehee DS | |
| (2002) Neuron. 33(6):905-919 | |
| EOD modulations of brown ghost electric fish: JARs, chirps, rises, and dips | |
| Zakon H, Oestreich J, Tallarovic S, Triefenbach F | |
| (2002) J Physiol Paris. 96(5-6):451-458 | |
| The long-term resetting of a brainstem pacemaker nucleus by synaptic input: a model for sensorimotor adaptation | |
| Oestreich J, Zakon HH | |
| (2002) J Neurosci. 22(18):8287-8296 | |
| Voltage-sensitive gating induced by a mutation in the fifth transmembrane domain of CFTR | |
| Zhang ZR, Zeltwanger S, Smith SS, Dawson DC, McCarty NA | |
| (2002) Am J Physiol. 282(1):L135-L145 | |
| The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-go-go-related gene (hERG) mutations | |
| Ficker E, Obejero-Paz CA, Zhao S, Brown AM | |
| (2002). J Biol Chem 277:4989-4998 | |
| Increased K+ efflux and apoptosis induced by the potassium channel modulatory protein KChAP/PIAS3 beta in prostate cancer cells | |
| Wible BA, Wang L, Kuryshev YA, Basu A, Haldar S, Brown AM | |
| (2002). J Biol Chem 277:17852-17862 | |
| Potassium channels Kv1.1, Kv1.2 and Kv1.6 influence excitability of rat visceral sensory neurons. | |
| Glazebrook PA, Ramirez AN, Schild JH, Shieh CC, Doan TN, Wible BA, Kunze DL | |
| (2002). J Physiol 541:467-482 | |
| Localization of the activation gate for small conductance Ca2+-activated K+ channels | |
| Bruening-Wright A, Schumacher MA, Adelman JP, Maylie J (2002). J Neurosci. 22(15):6499-6506 |
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| High-affinity blockade of human ether-a-go-go-related gene human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872 | |
| Thomas D, Wendt-Nordahl G, Rockl K, Ficker E, Brown AM, Kiehn J | |
| (2001). J Pharmacol Exp Ther 297:753-761 | |
| CFTR: covalent and noncovalent modification suggests a role for fixed charges in anion conduction | |
| Smith SS, Xuehong Liu X, Zhang ZR, Sun F, Kriewall TE, McCarty NA, Dawson DC | |
| (2001) J Gen Physiol. 118:407-431 | |
| CFTR: covalent modification of cysteine-substituted channels expressed in Xenopus Oocytes shows that activation is due to the opening of channels resident in the plasma membrane | |
| Liu X, Smith SS, Dawson DC | |
| (2001) J Gen Physiol. 118(4):433-446 | |
| Electrocardiographic prediction of abnormal genotype in congenital long QT syndrome: experience in 101 related family members | |
| Kaufman ES, Priori SG, Napolitano C, Schwartz PJ, Iyengar S, Elston RC, Schnell AH, Gorodeski EZ, Rammohan G, Bahhur NO, Connuck D, Verrilli L, Rosenbaum DS, Brown AM | |
| (2001). J Cardiovasc Electrophysiol 12:455-461 | |
| Molecular determinants of inactivation and dofetilide block in ether-a-go-go (EAG) channels and EAG-related K+ channels | |
| Ficker E, Jarolimek W, Brown AM | |
| (2001). Mol Pharmacol 60:1343-1348 | |
| Structure and complex transcription pattern of the mouse SK1 K(Ca) channel gene, KCNN1 | |
| Shmukler BE, Bond CT, Wilhelm S, Bruening-Wright A, Maylie J, Adelman JP, Alper SL (2001). Biochim Biophys Acta. 1518(1-2):36-46 |
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| U-type inactivation of Kv3.1 and Shaker potassium channels. | |
| Klemic KG, Kirsch GE, Jones SW | |
| (2001). Biophys J 81:814-826 | |
| Voltage-gated K+ channels in chemoreceptor sensory neurons of rat petrosal ganglion | |
| Andrews EM, Kunze DL (2001). Brain Res 897:199-203 |
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| A discrete animo terminal domain of Kv1.5 and Kv1.4 potassium channels interacts with the spectrin repeats of alpha-actinin-2 | |
| Cukovic D, Lu GW, Wible BA, Steele DF, Fedida D | |
| (2001). LEBS Lett 498:87-92 | |
| High-affinity blockade of human ether-a-go-go-related gene human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872. | |
| Thomas D, Wendt-Nordahl G, Rockl K, Ficker E, Brown AM, Kiehn J | |
| (2001). J Pharmacol Exp Ther 297:753-761 | |
| Mutations in the Kv beta 2 binding site for NADPH and their effects on Kv1.4 | |
| Peri R, Wible BA, Brown AM (2001). J. Biol Chem 276:738-741 |
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| KChAP/Kvbeta1.2 interactions and their effects on cardiac Kv channel expression. | |
| Kuryshev YA, Wible BA, Gudz TI, Ramirez AN, Brown AM | |
| (2001). Am J Physiol Cell Physiol 281:C290-C299 | |
| Drug-Induced Long QT Syndrome: Is HERG the Root of All Evil | |
| Brown AM, Rampe D. | |
| (2000). Pharmaceutical News. 7(4):15-20 | |
| KChAP as a chaperone for specific K+ channels | |
| Kuryshev YA, Gudz TI, Brown AM, Wible BA | |
| (2000). Am J Physiol Cell Physiol 278:C931-C941 | |
| BAX-dependent transport of cytochrome c reconstituted in pure liposomes | |
| Saito M, Korsmeyer SJ, Schlesinger PH | |
| (2000) Nat Cell Biol. 2:553-555 | |
| Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c | |
| Korsmeyer SJ, Wei MC, Saito M, Weiler S, Oh KJ, Schlesinger PH | |
| (2000) Cell Death Differ. 12:1166-1173 | |
| Interactions of the 5-hydroxytryptamine 3 antagonist class of antiemetic drugs with human cardiac ion channels | |
| Kuryshev YA, Brown AM, Wang L, Benedict CR, Rampe D | |
| (2000). J Pharmacol Exp Ther 295:614-620 | |
| Novel characteristics of a misprocessed mutant hERG channel linked to hereditary long QT syndrome | |
| Ficker E, Thomas D, Viswanathan PC, Dennis AT, Priori SG, Napolitano C, Memmi M, Wible BA, Kaufman ES, Iyengar S, Schwartz PJ, Rudy Y, Brown AM | |
| (2000). Am J Physiol Heart Circ Physiol 279:H1748-H1756 | |
| Functional suppression of sodium channels by beta(1)-subunits as a molecular mechanism of idiopathic ventricular fibrillation | |
| Wan X, Wang Q, Kirsch GE | |
| (2000). J Mol Cell Cardiol 32:1873-1884 | |
| Mechanisms of I(Ks) suppression in LQT1 mutants | |
| Bianchi L, Priori SG, Napolitano C, Surewicz KA, Dennis AT, Memmi M, Schwartz PJ, Brown AM | |
| (2000). Am J Physiol Heart Circ Physiol 279:H3003-H3011 | |
| Plasticity of the electric organ discharge: Implications for the regulation of ionic currents | |
| Zakon H, McAnelly L, Smith GT, Dunlap K, Lopreato G, Oestreich J, Few WP (1999). J Exp Biol. 202:1409-1416 |
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| Decreased sodium and increased transient outward potassium currents in iron-loaded cardiac myocytes | |
| Kuryshev YA, Brittenham GM, Fujioka H, Kanna P, Shieh CC, Cohen SA, Brown AM | |
| (1999). Circulation 100:675-683 | |
| Cystic fibrosis transmembrane conductance regulator: physical basis for lyotropic anion selectivity patterns | |
| Smith SS, Steinle ED, Meyerhoff ME, Dawson DC | |
| (1999) J Gen Physiol. 114:799-817 | |
| CFTR: mechanism of anion conduction | |
| Dawson DC, Smith SS, Mansoura MK | |
| (1999) Physio Rev. 79(1):S47-S75 | |
| Bicuculline block of small-conductance calcium-activated potassium channels | |
| Khawaled R, Bruening-Wright A, Adelman JP, Maylie J (1999). Pflugers Arch. 438(3);314-321 |
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| Cloning and expression of a novel member of the low voltage-activate T-type calcium channel family | |
| Lee JH, Daud AN, Cribbs LL, Lacerda AE, Pereverzev A, Klockner U, Schneider T, Perez-Reyes E | |
| (1999). J Neurosci 19:1912-1921 | |
| HERG encodes a K+ current highly conserved in tumors of different histogenesis: a selective advantage for cancer cells? | |
| Bianchi L, Wible BA, Arcangeli A, Taglialatela M, Morra F, Castaldo P, Crociani O, Rosati B, Faravelli L, Olivotto M, Wanke E | |
| (1998) Cancer Res 58:815-822 | |
| Cystic fibrosis transmembrane conductance regulator (CFTR) anion binding as a probe of the pore | |
| Mansoura MK, Smith SS, Choi AD, Richards NW, Strong TV, Drumm ML, Collins FC, Dawson DC | |
| (1998) Biophys J. 74(3):1320-1332 | |
| Modulation of potassium channel gating by coexpression of Kv2.1 with regulatory Kv5.1 or Kv6.1 alpha-subunits | |
| Kramer JW, Post MA, Brown AM, Kirsch GE | |
| (1998). Am J Physiol 274:C1501-C1510 | |
| Slo3, a novel pHsensitive K+ channel from mammalian spermatocytes | |
| Schreiber M, Wei A, Yuan A, Gaut J, Saito M, Salkoff L (1998). J Biol Chem. 273(6):3509-3516 |
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| Inactivation of Kv2.1 potassium channels | |
| Klemic KG, Shieh CC, Kirsch GE, Jones SW | |
| (1998). Biophys J 74:1779-1789 | |
| Cloning and expression of a novel K+ channel regulatory protein, KChAP | |
| Wible BA, Yang Q, Kuryshev YA, Accili E, Brown AM | |
| (1998). J Biol Chem 273:11745-11751 | |
| Inwardly rectifying K+ channels in dispersed bovine parathyroid cells | |
| McHenry CR, Stenger DB, Kunze DL | |
| (1998). J Surg Res 76:37-40 | |
| Separable effects of human Kvbeta1.2 N- and C-termini on inactivation and expression of human Kv1.4 | |
| Accili E, Kuryshev YA, Wible BA, Brown AM | |
| (1998). J Physiol 512:325-336 | |
| Molecular characterization of a neuronal low-voltage-actrivate T-type calcium channel | |
| Perez-Reyes E, Cribbs LL, Daud AN, Lacerda AE, Barclay J, Williamson MP, Fox M, Rees M, Lee JH | |
| (1998). Nature 391:896-900 | |
| Analysis of a Ca2+-activated K+ channel that mediates hyperpolarization via the thrombin receptor pathway | |
| Sullivan R, Koliwad SK, Kunze DL | |
| (1998). Am J Physiol 275:C1342-C1348 | |
| Genetic basis and molecular mechanism for idiopathic ventricular fibrillation | |
| Chen Q, Kirsch GE, Zhang D, Brugada R, Brugada J, Brugada P, Potenza D, Moya A, Borggrefe M, Breithardt G, Ortiz, Lopez R, Wang ZM, Antzelevitch C, O'Brien RE, Schulze-Bahr E, Keating MT, Towbin JA, Wang Q | |
| (1998). Nature 392:293-296 | |
| Mechanism of lidocaine block of late current in long Q-T mutant Na+ channels | |
| Dumaine R, Kirsch GE | |
| (1998). Am J Physiol 274:H477-H487 | |
| A role for L-type calcium channels in development regulation of transmitter phenotype in primary sensory neurons | |
| Brosenitsch TA, Salgado-Commissariat D, Kunze DL, Katz DM | |
| (1998). J Neurophysiol 18:1047-1055 | |
| Interactions of the nonsedating antihistamine loratadine with a Kv1.5-type potassium channel cloned from human heart | |
| Lacerda AE, Roy ML, Lewis EW, Rampe D | |
| (1997). Mol Pharmacol 52:314-322 | |
| A cysteine-rich domain defined by a novel exon in a slo variant in rat adrenal chromaffin cells and PC12 cells | |
| Saito M, Nelson C, Salkoff L, Lingle CJ (1997). J Biol Chem. 272(18):11710-11717 |
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| Open channel block of human heart hKv1.5 by the beta-subunit hKV beta 1.2 | |
| De Biasi M, Wang ZM, Accili E, Wible BA, Fedida D | |
| (1997). Am J Physiol 272:H2932-H2941 | |
| Stable expression and characterization of the human brain potassium channel Kv2.1: blockade by antipsychotic agents | |
| Wible BA, Murawsky MK, Crumb WJ Jr, Rampe D | |
| (1997). Brain Res 761:42-50 | |
| Separable Kvbeta subunit domains alter expression and gating of potassium channels | |
| Accili E, Kiehn J, Yang Q, Wang ZM, Brown AM, Wible BA | |
| (1997). J Biol Chem 272:25824-25831 | |
| Interactions among inactivating and noninactivating Kvbeta subunits, and Kvalpha2.3, produce potassium currents with intermediate inactivation | |
| Accili E, Kiehn J, Wible BA, Brown AM | |
| (1997). J Biol Chem 272:28232-23236 | |
| Contribution of the NH2 terminus of Kv2.1 to channel activation | |
| Pasqual JM, Shieh CC, Kirsch GE, Brown AM | |
| (1997). Am J Physiol 273:C1849-C1858 | |
| Role of transmembrane segment S5 on gating of voltage-dependent K+ channels | |
| Shieh CC, Klemic KG, Kirsch GE | |
| (1997). J Gen Physiol 109:767-778 | |
| Corticotropin releasing hormone inhibits an inwardly rectifying potassium current in rat corticotropes | |
| Kuryshev YA, Haak L, Childs GV, Ritchie AK | |
| (1997). J Physiol 502:265-279 | |
| Cystic fibrosis transmembrane conductance regulator: permeant ions find the pore | |
| Dawson DC, Smith SS | |
| (1997) J Gen Physiol. 110(4):337-339 | |
| CFTR activation: additive effects of stimulatory and inhibitory phosphorylation sites in the R domain | |
| Wilkinson DJ, Strong TV, Mansoura MK, Wood Dl, Smith SS, Collins FS, Dawson DC | |
| (1997) Am J Physiol. 273:L127-L133 | |
| Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2 | |
| chlesinger PH, Gross A, Yin XM, Yamamoto K, Saito M, Waksman G, Korsmeyer SJ | |
| (1997) Proc Natl Acad Sci USA. 94:11357-11362 | |
| Molecular physiology and pharmacology of hERG. Single-channel currents and block by dofetilide | |
| Kiehn J, Lacerda AE, Wible BA, Brown AM | |
| (1996). Circulation 94:2572-2579 | |
| Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current | |
| Post MA, Kirsch GE, Brown AM | |
| (1996). LEBS Lett 399:177-182 | |
| Corticotropin-releasing hormone stimulates Ca2+ entry through L- and P-type Ca2+ channels in rat corticotropes | |
| Kuryshev YA, Childs GV, Ritchie AK | |
| (1996). Endocrinology 137:2269-2277 | |
| Multiple mechanisms of Na+ channel-linked long-QT syndrome | |
| Dumaine R, Wang Q, Keating MT, Hartmann HA, Schwartz PJ, Brown AM, Kirsch GE | |
| (1996). Circ Res 78:916-924. | |
| Mapping the block of a cloned human inward rectifier potassium channel by dofetilide | |
| Kiehn J, Wible BA, Lacerda AE, Brown AM | |
| (1996). Mol Pharmacol 50:380-387 | |
| Comparison of Ca2+ loading and retention in isolated skeletal muscle triads and terminal cisternae | |
| Kramer JW, Corbett AM | |
| (1996). Am J Physiol 270:C1602-C1610 | |
| Oxidant stress activates a non-selective cation channel responsible for membrane depolarization in calf vascular endothelial cells | |
| Koliwad SK, Kunze DL, Elliott SJ | |
| (1996). J Physiol 491:1-12 | |
| Selectivity of ATP-activated GTP-dependent Ca(2+)-permeable channels in rat macrophage plasma membrane | |
| Naumov AP, Kaznacheyeva EV, Kuryshev YA, Mozhayeva GN | |
| (1995). J Membr Biol 148:91-98 | |
| A human calcium-activated potassium channel gene expressed in vascular smooth muscle | |
| McCobb D, Fowler NL, Featherstone T, Lingle C, Saito M, Krause JE, Salkoff L (1995). Am J Physiol. 269(3 Pt 2):H767-777 |
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| Gating of inwardly rectifying K+ channels localized to a single negatively charged residue | |
| Wible BA, Taglialatela M, Ficker E, Brown AM (1994). Nature 371(6494):246-249 |
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| Spermine and spermidine as gating molecules for inward rectifier K+ channels | |
| Ficker E, Taglialatela M, Wible BA, Henley CM, Brown AM (1994). Science 266(5187):1068-1072 |
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| Coupled secretion of chloride and mucus in skin of Xenopus laevis: possible role for CFTR | |
| Englehardt JF, Smith SS, Allen E, Yankaskas JR, Dawson DC, Wilson JR | |
| (1994) Am J Physiol. 267:C491-C500 | |
| Specification of pore properties by the carboxyl terminus of inwardly rectifying K+ channels | |
| Taglialatela M, Wible BA, Caporaso R, Brown AM (1994). Science 264(5160):844-847 |
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| Heterologous regulation of the cardiac Ca2+ channel alpha 2 subunit by skeletal muscle beta and gamma subunits | |
| Wei XY, Perez-Reyes E, Lacerda AE, Schuster G, Brown AM, Birnbaumer L | |
| (1991). J Biol Chem 266:21943-21947 | |
| A new site for the activation of cardiac calcium channels defined by the nondihydropyridine FPL 64176 | |
| Rampe D, Lacerda AE | |
| (1991). J Pharmacol Exp Ther 259:982-987 | |
| Internal and external TEA block in single cloned K+ channels | |
| Kirsch GE, Taglialatela M, Brown AM | |
| (1991). Am J Physiol 261:C583-C590 | |
| Exchange of conduction pathways between two related K+ channels | |
| Hartmann HA, Kirsch GE, Drewe JA, Taglialatela M, Joho RH, Brown AM (1991) Science 251(4996):942-944 |
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| Expression of ion channels and mutational effects in giant Drosophila neurons differentiated from cell division-arrested embryonic neuroblasts | |
| Saito M, Wu CF (1991). J Neurosci. 11(7):2135-2150 |
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| Parathyroid hormone: an endogenous modulator of cardiac calcium channels | |
| Rampe D, Lacerda AE, Dage RC, Brown AM | |
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| Normalization of current kinetics by interaction btween the alpha 1 and beta subunits of the skeletal muscle dihydrophridine-sensitive Ca2+ channel | |
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| (1991). Nature 352:527-530 | |
| Electrophysiological characterization of a new member of the RCK family of rat brain K+ channels | |
| Kirsch GE, Drewe JA, Verma S, Brown AM, Joho RH | |
| (1991). LEBS Lett 278:55-60 | |
| [3H]PN200-110 binding in a fibroblast cell line transformed with the alpha 1 subunit fo the skeletal muscle L-type Ca2+ channel | |
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| (1990). Biochem Biophys Res Commun 169:825-831 | |
| Alteration and restoration of K+ channel function by deletions at the N- and C- termini | |
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| Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes | |
| Kirsch GE, Codina J, Brown AM | |
| (1990). Am J Physiol 259:H820-H826 | |
| Induction of calcium currents by the expression of the alpha 1-subunit of the dihydropyridine receptor from skeletal muscle. | |
| Perez-Reyes E, Kim HS, Lacerda AE, Horne W, Wei XY, Rampe D, Campbell KP, Brown AM, Birnbaumer L | |
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| Nonmodal gating of cardiac calcium channels as revealed by dihydropyridines | |
| Lacerda AE, Brown AM | |
| (1989). J Gen Physiol 93:1243-1273 | |
| Trypsin activation of atrial muscarinic K+ channels | |
| Kirsch GE, Brown AM | |
| (1989). Am J Physiol 257:H334-H338 | |
| Angiotensin II modulates cardiac Na+ channels in neonatal rat | |
| Moorman JR, Kirsch GE, Lacerda AE, Brown AM | |
| (1989). Circ Res 65:1804-1809 | |
| Modification of Na channel gating by an alpha scorpion toxin from Tityus serrulatus | |
| Kirsch GE, Skattebol A, Possani LD, Brown AM | |
| (1989). J Gen Physiol 93:67-83 | |
| Sodium channel kinetics in normal and denervated rabbit muscle membrane | |
| Kirsch GE, Anderson MF | |
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